Sir Anthony Hopkins (Dr. Hannibal Lecter), Anthony Heald (Dr. Frederick Chilton), and Frankie Faison (Barney Matthews) all reprised their roles from earlier movies in the franchise. Faison is the only one to have appeared in the first four Thomas Harris "Hannibal" adaptations, having also appeared in Manhunter - Frammenti di un omicidio (1986) in a different role.

Film

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