The Investigative Support Unit ("Mindhunters" is slang for the ISU) is the FBI's special force that has assisted state and local police in cracking some of the United States' most notorious serial murder cases. Mindhunters specialize in understanding and profiling the chemistry and mechanical workings of the brain in these serial criminals. Mindhunters train in a multidisciplinary capacity, including highly demanding field training and research of such murderers as Charles Manson and David Berkowitz (the Son of Sam).

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