Andy Garcia was originally offered the lead role, a character who would have been named Detective Rick Calucci. He declined the role, as did Ray Liotta. While in talks with franchise creator Anthony E. Zuiker about taking on the role of the lead character, Gary Sinise asked that the characters name be changed to Mac Taylor in memory of his brother-in-law, McCanna ("Mac") Harris, a decorated Vietnam vet who had died of cancer in the 1980s. (The "Taylor" is a nod to his most iconic character, Lt. Dan from Forrest Gump (1994)).

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